101 Damnations takes aim and tells the story of a Hitman who returns to his former employer in order to seek vengeance on behalf of his best friend, his dog. Even though his boss tries to make amends by giving the gift of a new puppy, the Hitman cannot be swayed in his mission to avenge the death of his dog. Now, he must make a daring escape while protecting his new puppy and killing anyone who stands in his way.