Metal Gear Solid: Acquiescence is centering around the game series' hero Solid Snake. The story follows Snake on his first mission for the secret organization known as Foxhound. After being deployed to Coloso, Colombia, he infiltrates a factory to retrieve a hostage scientist and data concerning the development of a new, secret weapon. Soon after his insertion, things go wrong and he is in a fight for his life against a murderous, draconian leader; hellbent on the production of a weapon that could turn the tide of any war.