Nature vs nurture, science vs faith, logic vs love. On their last night together, two women wonder through an empty city as they face the reality of their relationship that's withering. Roma, a humble soul from the country wilderness of central Pennsylvania, embarks on a trip to the city of Philadelphia where she has been living for the past year and a half. While living in the city she meets Lydia, a witty biochemistry student, who soon became her lover. Their lives and loves clash with one another but it's the true character of each that keeps them rooted in one another.